Hopefully this image will make it easy to understand what we’re about to explain.
The house in this image is the Cancer Tumor
The individual cancer cells are inside the house(tumor) like tables, chairs, rooms, etc.
The workers/gardeners in the garden are Cancer-Associated Fibroblasts (CAFs)
The Garden is the Stroma, or the tumor environment
The Signal is TGFB which gives orders to the workers(CAF).

The CAFs build and repair inside the Tumor(house).
The Stroma(Garden) is crucial for CAFs, providing the necessary support, resources, and environment for them to effectively assist in tumor maintenance and growth. The stroma gives nutritional supply to CAFS for them to work.
The Stroma(garden) is made out of soil, mulch, seeds. 
There’s a supportive network made of proteins outside cells called Extracellular Matrix (ECM).
The ECM is in the Stroma(Garden). 
Think of ECM as soil, mulch, and other materials that provide structure and nutrients, supporting the garden plants.
This ECM is primarily made out of Collagen
Collagen is fibrous material.
It is because of Collagen that the Stroma is a dense wall where immune cells cannot penetrate nor can chemo.
Collagen plays a vital role in the tumor environment and the interactions between CAFs, the stroma, and cancer cells:
Role of Collagen:

• Structural Component: Collagen is a major part of the extracellular matrix (ECM), providing structure and strength to the tumor stroma.

• Support for CAFs: CAFs produce and remodel collagen, helping to maintain the integrity of the stroma and facilitating their own function.

• Tumor Progression: Collagen can influence tumor cell behavior, promoting invasion and metastasis by creating a favorable environment for cancer cells to thrive.

• Signaling: Collagen interacts with receptors on cancer and CAFs, triggering signaling pathways that affect growth and survival

Supplementing with Collagen is a bad idea for a cancer patient.
Now, how do we work around this to get chemo or any other killing agent to gain access into the house(tumor).
Well, the first one we mentioned which is Fenbendazole disrupting this Stroma wall.
We can also target the CAFs/the workers.
We can also target the TGFB which gives the workers the orders.
Before we mention the CAFs and TGFB agents, we’re going to mention another agent that disrupts the Stroma wall.
Paricalcitol(a form of Vitamin D) also disrupts the Stroma.
Losartan, a high blood pressure drug disrupts the Stroma

Targeting CAFs:
Cannabis Oil impairs the activation of CAFs
We have seen a few testimonials of Cannabis Oil working for pancreatic cancer this is one of the reasons why.
Here is an image of drugs and natural compounds that target CAFs
That image is from this study
Some of these compounds don’t directly target CAFS but they do indirectly block the function of CAFs and some of these compounds like Curcumin, EGCG and Resveratrol block cancer’s other pathways so 2 birds with one stone results you’re getting by using these things. 
Not only are these compounds targeting CAFs but these compounds also block cancer’s many pathways like metabolic pathways and other signaling pathways.
It could be that extra one thing you took like Curcumin or Resveratrol or EGCG or Baby Aspirin that made the difference to put you over the top to kill cancer once and for all. 
That is why we love the saying throw the kitchen sink at it. 

Targeting TGFB
Losartan, as mentioned earlier, not only does it disrupt the Stroma but it also blocks TGFB. 
Losartan also blocks collagen deposition into the tumor
Losartan trial used in pancreatic cancer patients article
Losartan with chemo made a patient eligible for whipple surgery

Irbesartan, another high blood pressure drug inhibits TGFB.
Here is a case study of a stage 4 colon cancer patient where chemo and radiation failed and Irbersartan worked, complete response to Irbesartan by blocking TGFB at a dose of 150 mg daily.

Thymoquinone(a compound in Black Seed Oil) inhibits TGFB
Cancer studies show 5 grams of Black Seed oil is sufficient to have an effect.
1 tsp black seed oil = 4.5 – 5 grams
You can take 1 tsp, twice a day

Jane McLelland recommends Hydroxychloroquine or Dipyridamole for inhibiting TGFB.

As you can see, these re-purposed drugs and supplements are fighting against cancer in many ways that we