Ivermectin

Caution: Although rare but Ivermectin can cause neurotoxicity. It does not belong in the brain. MDR1 gene defect causes Ivermectin to enter the brain.

It has come to our attention that people have reported side effects with this drug, primarily vision problems. One lady reported that she got permanent blurry vision from using Ivermectin. Others have reported blurry vision as well but once they stopped taking the drug their blurry vision resolved. 
Here’s one fact most people don’t know; the eyes are part of the brain. 
We investigated these reports to see if they were true or not. Although Ivermectin has been in use for humans for so many years, recently the use of Ivermectin has skyrocketed in the last few months due to social media and a Doctor named Dr William Makis releasing a protocol that includes Ivermectin and Fenbendazole in treating cancer.
Click here for the protocol
Ivermectin use for animals is prominent, specially dogs.
We have seen reports of dogs dying due to this drug. We then learned that dogs can have a faulty MDR1 gene.
This gene encodes P-glycoprotein (P-gp).
P-gp is a protein that pumps certain substances out of cells. It’s especially active in places like:
The blood-brain barrier (BBB), intestines, liver and the kidneys

MDR1 = the gene
P-gp = the protein

If this MDR1 gene is faulty then drugs that are not meant to enter the brain like Ivermectin, pass through into the brain and can cause neurotoxicity.
Pet owners are advised to test their dogs for this gene before using Ivermectin.
The cost of this test is less than $100 for pet owners.
Well, apparently humans can have a faulty MDR1 gene as well.
Unfortunately since this is a genetic test, it’s not available at your local lab. It’s a private genetic test and it costs over $1000.
This MDR1 gene is also known as the ABCB1 gene.
If you ever want to get this test, here is one place where you can get it done:
Click here for the test
We have found published case studies of Ivermectin neurotoxicity in humans.
Click Here for the study
Here’s an excerpt from this study:

“mdr-1 gene variants in humans allowing ivermectin penetration into the central nervous system”.

At the blood-brain barrier (BBB), P-glycoprotein acts like a bouncer, keeping many potentially toxic substances out of the brain.
If P-gp is working properly: It can prevent neurotoxic drugs or chemicals from accumulating in the brain.

Another way Ivermectin can cause neurotoxicity without the MDR1 gene defect is indirectly lowering P-gp expression.
Indirectly as in, Ivermectin inhibits EGFR which then lowers P-gp expression.
Low P-gp expression then obviously means lower bouncers(P-gp) at the blood brain barrier so then Ivermectin accumulates in the brain. In this case the dosage makes the poison and that is why we’re against high dosages and we don’t believe Ivermectin should be taken every day because it’s fat soluble and it accumulates in fatty tissues.
It has a half life of 18 hours so after 18 hours there is still 50% of ivermectin in the blood.
So as you can imagine, if someone is taking it multiple times a day and taking it every day then it’s going to have accumulating effects on dosage count and causes concern for neurotoxicity in our view.

We’re not in any way trying to discourage people not to use Ivermectin but just to keep an eye on neurotoxicity symptoms.
We’re just putting this caution up so people are aware. If you decide to take this drug, then watch out for any neurotoxicity symptoms, specially vision problems.

Having said all that, we believe Ivermectin is a very powerful drug against cancer.
We have seen many testimonials of people curing their cancer with just Ivermectin alone. 

Here is how Ivermectin is effective against cancer.
Ivermectin is a de-wormer drug like Fenbendazole.
It also disrupts the function of Microtubules inside cells just like Fenbendazole.
A Microtubule has many functions inside a cell, one of the primary ones is cell division and grow.
One of the functions of a microtubule is cell division and growth. 
One of the functions of a microtubule is cell division and growth. Without cell division and growth as you can imagine the cancer cells cannot divide and multiply and grow.
Cancer cells need lots of energy to grow fast. Ivermectin can mess with their mitochondria, which are like tiny power plants inside each cell.
It makes the mitochondria leak and produce too many reactive oxygen species (ROS) — like little chemical sparks.
These sparks damage the cell from the inside, eventually triggering cell death.
Cancer cells often use certain “messenger” systems to tell themselves to keep growing and not die.
One of these systems is called WNT/β-catenin.
Ivermectin can block this system, so the cancer cell stops getting growth signals and becomes weaker.
Some cancer cells try to hide or pump out chemo drugs using special proteins like P-glycoprotein.
Ivermectin blocks this pump, which makes chemo more effective.
Makes the cancer more visible to the immune system.
Healthy cells know when to retire and go through programmed cell death known as apoptosis but cancer cells ignore that.
Ivermectin can reactivate this suicide program, called apoptosis, using proteins like caspases.
The cell gets a signal like: “You’re broken — time to go,” and shuts itself down.
Cancer cells build their own “city,” including blood vessels to feed them.
Ivermectin may block the growth of these new blood vessels (angiogenesis).
Without food and oxygen, the tumor shrinks.
Ivermectin turns cold tumors hot.
A cold tumor is a type of cancer that doesn’t provoke a strong immune response.
Cold tumors is when there’s no activity of immune cells against the tumor.
Cold tumors resist immunotherapy drugs.
Ivermectin synergizes with immunotherapy drugs.
As for the dosage, although Ivermectin has been in use for decades, it was used in dosages of usually 0.2 mg/kg body weight, which roughly equates to 12 mg tablet taken once or taken 1 to 2 weeks apart in some cases.
Cancer patients are using the 0.2 mg/kg body weight calculation and taking it once a day for 1 week and 1 week off and most people do fine with this dose without any side effects.
We whole heartedly believe someone with cancer should definitely incorporate Ivermectin in their protocol against cancer but just be cautious of any neurotoxicity symptoms.