NATURAL IMMUNOTHERAPY

Immunotherapy is a type of treatment that helps your immune system fight diseases like cancer.
Cancer finds clever ways to hide from the immune system.

What are PD-1 and PD-L1?

To understand this, think of your immune system like a security team with guard dogs (called T-cells). These guard dogs check all the cells in your body to see if they’re safe.

Now, here’s where PD-1 and PD-L1 come in:

PD-1 is a “brake” on the T-cell. It’s a protein found on the surface of the T-cell.

PD-L1 is like a “fake ID” that some cells (including cancer cells) can show to the T-cell to say: “Hey, I’m safe, don’t attack me!”

When PD-L1 from a cancer cell connects with PD-1 on a T-cell, it tells the T-cell to stand down and not attack. This helps cancer cells hide from the immune system.

How do immunotherapy drugs work here?

There are special immunotherapy drugs called PD-1 inhibitors or PD-L1 inhibitors. These drugs block the connection between PD-1 and PD-L1.

It’s like taking the “brake” off the T-cell or ripping up the cancer cell’s fake ID.

That way:

The T-cells see the cancer cells for what they really are.

The immune system can attack and kill the cancer cells like it’s supposed to.

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Summary

Immunotherapy = helping your immune system fight cancer.

PD-1/PD-L1 = a trick cancer uses to hide from immune cells.

Immunotherapy drugs = block that trick, so the immune system can fight the cancer better.

This short animated Youtube video will help you more to understand this hopefully.

Melatonin
This is hormone released by your brain at night time to tell your body that it’s time to sleep.
Sleeping does not produce Melatonin, it’s rather produced when it gets dark(night time) to make you feel sleepy.
This is why sleep is very important at night time and nightshift jobs are not healthy because it messed up with the production of melatonin and your your body’s natural 24-hour clock, mainly set by light and dark signals.
That’s because Melatonin is your body’s natural immunotherapy as it blocks PD1 and PD-L1.
Click here for the Melatonin study that shows it increases your immune T-Cells and suppressed PD-1
Click here for the study where Melatonin suppressed PD-L1

50 mg/kg mice study was sufficient to decrease tumor size.
This would equate to 4 mg/kg in humans. 
For a 60 kg human that would mean 243 mg Melatonin.
I guess this is why high dose melatonin is recommended by Riordan Clinic.

Flubendazole
This is a anti-parasitic drug just like Fenbendazole.
Flubendazole also disrupts the microtubule of cancer cells just like Fenbendazole.
However the one unique and very very important aspects of this drug is, it’s a natural immunotherapy drug.
It blocks PD-1.
It doesn’t directly block PD-1 like the immunotherapy drugs on the market so because of this it doesn’t carry the harsh side effect risks like those drugs but nevertheless it can block the PD-1 which is huge in the treatment of cancer.
The minor issue is where to buy it and what the actual dose is.